Buffalo Bills (8-6) set to clash with Los Angeles Chargers (5-9) at SoFi Stadium in Week 16.

Chargers fire head coach Brandon Staley and GM Tom Telesco amid season struggles.

Chargers' QB Justin Herbert sidelined with a broken finger since Week 14.

Bills soar with a dominant 31-10 win over Dallas, thanks to RB James Cook's standout performance.

Bills may face challenges with injuries to key players AJ Epenesa and Micah Hyde.

Betting predictions favor the Bills: BetMGM, ESPN, and Dimers all predict Buffalo's victory.

BetMGM NFL odds make the Bills favorites against the Chargers.

ESPN gives the Bills an 81.7% chance of triumphing in Week 16.

Dimers' predictive model foresees the Bills winning 25-16.